What is the Endocannabinoid System?

When it comes to understanding CBD oil and its purpose, it is important to have some knowledge of the human endocannabinoid system - or ECS. We know that cannabinoids have an effect on our bodies, but what allows them to have this effect and how does it all work?

As it turns out, it all comes down to the Endocannabinoid System. In this blog post, we'll look at the ECS and all it can do. First, though, it is crucial to understand the concept of homeostasis. 

What is Homeostasis?

Homeostasis refers to the regulation of conditions in the body, such as body temperature, blood sugar levels, water content, and more. In order for the body to function properly, our bodies need to remain within certain parameters that prevent us from getting sick, and help us to live normally. 

We can maintain homeostasis by using negative feedback mechanisms. This means that everything in our bodies are monitored carefully, so that, when something changes, we can quickly and easily correct it. This is where the ECS comes in. 

The Endocannabinoid System

The endocannabinoid system is a network of endocannabinoids and cannabinoid receptors that exist throughout our bodies. It is thought to exist in most animals, and it is critical to our survival. 

The cannabinoid receptors exist on the surface of cells and essentially listen to what is happening inside of the body. They communicate this information about out bodies' status and changing circumstances to the inside of the cell, allowing for the appropriate measures to be taken. In simpler terms, they allow for us to maintain homeostasis by monitoring what is happening within our bodies. 

Scientists have identified 2 primary cannabinoid receptors, called the CB1 and CB2 receptors. Both can be found all throughout the body, but CB1 receptors are more highly concentrated in the brain and central nervous system. CB2 receptors are more abundantly found within the immune system, organs, and tissues. 

The body produces its own cannabinoids, and we call them endocannabinoids. These molecules are created whenever we need them, usually as a response to a change in the body. They can bind directly with the cannabinoid receptors. 

Currently, scientists have identified 2 major endocannabinoids called anandamide and 2-AG. Endocannabinoids are made from fat-like molecules within the cell membranes. Once the endocannabinoids have fulfilled their usage, metabolic enzymes are able to break them down again. 

FAAH breaks down anandamide, while MAGL breaks down 2-AG. This ensures that the endocannabinoids aren't used for longer than necessary. This process is what separates endocannabinoids from other molecular signals, such as hormones or neurotransmitters, which can be stored in the body. 

The Role of the Endocannabinoid System in the Body

Along with maintaining homeostasis, the ECS plays an extremely large role in keeping us healthy. It is thought that having a deficiency of endocannabinoids could cause a huge range of complications in the body. If we don't have enough endocannabinoids, we can't fix certain problems that arise. This relates to both mental and physical complications.

Basically, anything that homeostasis helps to regulate, the ECS will be involved in. As we mentioned, this makes the ECS an incredibly important system in the body.

How do Cannabinoids Interact with the ECS?

With over 100 cannabinoids naturally occurring in the cannabis plant, each one can interact with out endocannabinoid system in different ways. THC and CBD are the most well known and well studied, and have gained the most public interest.

Tetrahydrocannabinol, or THC, is the most infamous active compound in cannabis, and it has the ability to interact directly with our ECS. When marijuana is used, the THC binds directly with our cannabinoid receptors, in the same way as our endocannabinoids do. The down side is that THC binds to the CB1 receptors in the brain, which is why THC can cause psychoactive, intoxicating effects and product a high.

Cannabidiol is very different, however. Instead of binding directly with our cannabinoid receptors, it has an indirect influence on the ECS. It can help us produce more endocannabinoids naturally, which leads to a better functioning of the ECS and a healthier body. For this reason, CBD continues to be researched for its potential.

When you consume CBD oil or another CBD product, such as gummies or capsules, you are absorbing CBD into your bloodstream and allowing it to interact with the ECS. If your endocannabinoid system is struggling to maintain homeostasis, CBD can give it that needed boost.



As we've learned, the ECS is a crucial system in the human body. It not only is critical for our survival, but it is fundamental in understanding the impact that CBD could have on our bodies. 

The existence of the endocannabinoid system is very encouraging for the CBD industry, as it clearly shows why CBD can have such a powerful and positive impact on humans, and more recently, pets too!

Here, at Emperors Best, we can guarantee our CBD is 100% pure and non-GMO. Our products contain no fillers, chemicals, pesticides, solvents, or herbicides, and is formulated and bottled right on property. We offer both full spectrum and broad spectrum CBD products that are completely safe and legal for consumption. Check out our online store, stop in, or call us at 1-888-687-4334 for any questions!

Please consult with your doctor or other qualified medical professional before taking any medication, supplements, or beginning a health regimen. 

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